The U.S. Navy tweeted there are "several confirmed injuries with reports of fatalities."
A shooter was "contained" but not yet in custody, and was believed to be barricaded in a building on site, an official told The Associated Press.
The injured included a Washington police officer who has been hospitalized, and a base security guard officer, said Metropolitan Police Department spokeswoman Saray Leon.
The incident occurred at 8:20 a.m. when several shots were fired inside the headquarters for Naval Sea Systems Command in southeast Washington. An "active shooter" remained inside the building, the Navy said.
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